GRK2 in Lymphocytes
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چکیده
منابع مشابه
GRK2 in Lymphocytes
Heart failure (HF) has been described as the inability of the myocardium to deliver oxygen and nutrients to a degree commensurate with the metabolic requirements of the body. Myocardial dysfunction induces compensatory neurohumoral mechanisms, including the sympathetic nervous system (SNS), as an attempt to preserve contractile performance. Mediators of the SNS consist predominantly of 2 catech...
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MOTIVATION Epithelial Na(+) channels (ENaC) mediate the transport of sodium (Na) across epithelia in the kidney, gut and lungs and are required for blood pressure regulation. They are inhibited by ubiquitin protein ligases, such as Nedd4-2. These ligases bind to proline-rich motifs (PY motifs) present in the C-termini of ENaC subunits. Loss of this inhibition leads to hypertension. We have prev...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2016
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.116.308542